UK Flexible Sigmoidoscopy Screening Trial
The UK Flexible Sigmoidoscopy Screening Trial (UKFSST) started in 1994 and is still on-going. The trial has received funding from a number of government and charitable sources including:
- the UK Medical Research Council
- the National Institute for Health Research Efficacy and Mechanism Evaluation programme
- the National Institute for Health Research Health Technology Assessment programme
- Cancer Research UK
- KeyMed Ltd
The UKFSST is a major research study and recruited over 170,000 people from across the UK. The first results assessing the effectiveness of the screening tested in this trial were published in 2010. The results confirmed that the test was very effective at preventing bowel cancer and very long-lasting. This study led directly to the introduction of flexible sigmoidoscopy (bowel scope/Flexi-scope) screening in the NHS English Bowel Cancer Screening Programme.
Harpal Kumar, Chief Executive of Cancer Research UK said of the UKFSST:
“Cancer Research UK does not often use the word ‘breakthrough’ but this is one of those rare occasions when I am going to. It is extremely rare to see the results of a clinical trial which are quite as compelling as this. Flexi-scope needs to be brought in as soon as possible. Every week of delay will risk scores of lives.”
The trial is registered with the ISRCTN registry. Its unique number is 28352761.
Our Data Protection and Privacy Notice
This privacy notice explains your rights to your personal information, what you can expect us (the Cancer Screening and Prevention Research Group) to do with your personal data and our lawful basis for doing so. This notice also explains who you should contact if you have any queries or complaints about how we are processing your personal data.
Under the 2018 General Data Protection Regulation (GDPR) and accompanying Data Protection Act (2018) ‘personal data’ is any data that can be linked to an identifiable individual (for a full definition see: Information Commissioners Office [ICO] website: What is Personal Data?). Some types of personal data, such as health data, are additionally classified as ‘special category personal data’. The law considers special category personal data to be more sensitive and gives it more legal protection (for more information see: ICO website: Special Category Data). As the Cancer Screening and Prevention Research Group processes (processing is the term used to refer to collecting, analysing and storing data) health data, much of the personal data we hold is considered to be special category personal data.
Who is responsible for the lawful processing of your personal data?
The GDPR and Data Protection Act define roles and responsibilities for those involved in processing personal data.
The Cancer Screening and Prevention Research Group (hereafter; CSPRG) are a research group at Imperial College London. The CSPRG can be contacted via the ‘Contact Us’ page on this website. The data controller determines the purpose for which and the manner in which personal data is to be processed see ICO website: Controllers and Processors. For the personal data held by the CSPRG, the data controller is Imperial College London. The data controller’s representative for our data is the Director of Information Governance for Academic Health Sciences. All queries relating to the handling of personal data should be directed to the Imperial College London Data Protection Officer via email at email@example.com. Contact details can also be found at the end of this privacy notice.
Why are we processing personal data?
The research focus of the CSPRG is bowel cancer, also known as colorectal cancer. In the UK, every year over 41,000 people are diagnosed with bowel cancer and 16,000 people die from this disease. Through our research we hope to reduce the number of people being diagnosed with bowel cancer and dying from this disease. Much of our work focuses on how to help make bowel cancer screening and surveillance programmes more effective and acceptable for patients, and more efficient for the NHS, and other health services internationally. To understand the effectiveness of bowel cancer screening and surveillance programmes, we conduct large scale studies on procedures conducted and the benefits to patients. Identifiable patient data are usually necessary to track long-term health outcomes from participants enrolled in our studies. The CSPRG therefore needs to collect and hold personal data – often special category personal data. Our more specific purposes for processing data for each of our studies are detailed on the ‘Studies’ pages of our website.
What personal data do we have?
The personal data we hold is special category personal data relating to individual health. For example, for several of our studies we analyse procedure and treatment information, information about cancers occurring, whether they progress and the patients’ long-term health outcomes. In addition, we also often require some basic information about patients such as age and gender to inform our analysis. The full details of the personal data processed for each of our studies can be found on the ‘Studies’ page of our website.
To fulfil our research aims we obtain personal data from a variety of sources. Much of our data is either obtained directly from NHS Trusts, or via third parties such as NHS Digital, the Office for National Statistics, the Bowel Cancer Screening Programme, National Cancer Registries (including the Welsh Cancer Intelligence and Surveillance Unit) and Information Services Division Scotland, part of NHS National Services Scotland. More detailed explanations of our sources of data can be found on the ‘Patient Data’ page and ‘Studies’ pages of our website.
Where data has been obtained from third party data providers under section 251 approval, national data opt-outs have been applied by the provider since 2016.
How do we process personal data?
All personal data we hold are processed in secure systems. For each active study we have completed a Data Protection Impact Assessment that has been approved by the Head of the CSPRG (as the Information Asset Owner) and the Imperial College London Data Protection Officer. No processing performed by the CSPRG involves automated decision-making or profiling. Unless stated otherwise on the ‘Studies’ pages of our website, all personal data are processed exclusively by the CSPRG. None of our studies process or transfer personal data outside the UK.
The Imperial College Data retention schedule mandates that data is retained for ten years after the end of a study (see the College Retention Schedule here). The expected end of these ten year retention periods for each of our studies are listed under the ‘Studies’ pages of our website under the ‘How long will we retain the data?’ sections.
What is our lawful basis for processing personal data?
Processing personal data requires justification under two legal frameworks: the GDPR/Data Protection Act 2018 and under the common law duty of confidentiality.
Article 6 of the GDPR lays out eight valid bases under which personal data can be processed lawfully. We process personal data under lawful basis 6(e) ‘Public task’ as: processing is necessary for the performance of a task carried out in the public interest. We are also required to have a separate lawful basis for processing the more sensitive special category personal data. Our legal basis for processing special category personal data is Article 9(j) ‘processing is necessary for archiving purposes in the public interest, scientific or historical research purposes or statistical purposes […]’
In addition, health data (such as that the CSPRG hold) require a separate lawful basis under the common law duty of confidentiality. In some of our studies, patients consented to be part of the study and for the CSPRG to process their data. In other studies, consent could not be sought due to practical considerations or the nature of the study. In these studies, we have obtained lawful permission to obtain and process personal data under section 251 of the National Health Act 2006. The common law legal bases for data processing in each study are explained in the ‘Studies’ pages of our website under the ‘What approvals has the study received?’ sections.
What are your rights concerning your personal data?
The GDPR grants individuals several rights concerning their personal data:
- The right to object (to processing of the data)
- The right to correct (inaccurate or incomplete data)
- The right to erasure (also known as “the right to be forgotten”)
- The right to restrict processing (e.g. while the accuracy of the data is contested)
- The right to portability (to have a copy of any data you have provided to us)
- The right to access (to have a copy of data we hold about you)
- The right to withdraw consent (if you have previously consented to take part)
If you think that we might be processing your data and you wish to exercise any of the rights listed above, please get in touch using the details on the Contact Us page or by contacting the Imperial College London Data Protection Officer via email at firstname.lastname@example.org. Though it may not always be possible for us to fulfil your request, we will respond to your query within one month. For more information on your GDPR rights, please see guidance provided by the Information Commissioners Office.
Where can you direct queries or complaints?
Please be aware that individuals also have a right to complain to a supervisory authority- in this case the Information Commissioners Office (ICO) – if they feel their data is being used unlawfully. The ICO does recommend that you seek to resolve matters with the data controller – for our data that is Imperial College London – before contacting the commissioner’s office. If you wish to raise a complaint on how we have handled your personal data or if you want to find out more about how we use your data, please contact Imperial College London’s Data Protection Officer via email at email@example.com, via telephone on 020 7594 3502 or via post at Data Protection Officer, Faculty Building Level 4, Imperial College London, London SW7 2AZ. If you are not satisfied with our response or believe we are processing your personal data in a way that is not lawful you can raise your complaint with the Information Commissioner’s Office.
Privacy and data protection information relating specifically to the UKFSST study
The CSPRG at Imperial processes special category personal data for the UKFSST study. We use this special category personal data to examine the long-term effectiveness of a once-only flexible sigmoidoscopy. Effectiveness, in this case, refers to reduced incidence of colorectal cancer, and a reduced chance of colorectal cancer induced mortality. To determine this effectiveness, we need to process special category personal data relating to cancer incidence and mortality for participants enrolled in the trial. The special category personal data used in this study is crucial to the success of this project, and the public good generally.
Imperial College London, as data controllers for the CSPRG, are the receipt of special category personal data for the UKFSST. The special category personal data for the UKFSST are received by the CSPRG from several sources.
- NHS Hospitals. The flexible sigmoidoscopy procedures were carried out in NHS Hospitals in England, Scotland and Wales. These hospitals transferred the UKFSST trial data (i.e. the details of the procedure and relevant clinical data) to the CSPRG. The 16 NHS Hospitals that participated in this study were: Bolton Hospital, Christie Hospital, John Radcliffe Hospital, Leeds General Infirmary, Leicester General Hospital, Norfolk and Norwich Hospital, Queen Alexandra Hospital, Queen Elizabeth Hospital, Gateshead-Newcastle General Hospital, Queen Elizabeth II Hospital, Royal Liverpool Hospital, St Marks Hospital, Royal Gwent Hospital, Newport/Llandough Hospital, Singleton Hospital and Glasgow Royal Infirmary.
- NHS Digital. NHS Digital collect and process data from across the health and social care system in England. For the UKFSST, NHS Digital provide the CSPRG with: cancer incidence and mortality for patients in England and Wales; cause of death data for patients in England and Wales (see Office for National Statistics below); and colorectal cancer screening data for patients in England (see Bowel Cancer Screening Programme below). Some of these data are provided to NHS Digital from other sources, described below.
- The Bowel Cancer Screening Programme. The Bowel Cancer Screening Programme is part of Public Health England and manages screening tests for bowel cancer in England. The Bowel Cancer Screening Programme provide the CSPRG (via NHS Digital) with colorectal cancer screening data for participants enrolled in the UKFSST study in England.
- Office for National Statistics. The Office for National Statistics provide cause of death data for patients enrolled in this study from England and Wales. This information is provided to the CSPRG via NHS Digital.
- The National Cancer Registration and Analysis Service. The National Cancer Registration and Analysis Service processes data about the progression and treatment of cancers in patients in England. During the UKFSST trial, cancer incidence, mortality and staging data are provided to the CSPRG by the National Cancer Registration and Analysis Service.
- Welsh Cancer Intelligence and Surveillance Unit. In Wales, cancer staging data is collected by the Welsh Cancer Intelligence and Surveillance Unit. For patients in Wales enrolled in the UKFSST, the Welsh Cancer Intelligence and Surveillance Unit provide cancer staging data to the CSPRG.
- NHS National Services Scotland. The Information Services Division of NHS National Services Scotland manage the processing of health and care data in Scotland. For UKFSST participants in Scotland, NHS National Services Scotland provided the CSPRG with cancer incidence and mortality data, cancer staging data and cause of death data.
- NHS Central Register. For UKFSST participants moving from England to Scotland during the trial, cancer incidence and mortality data, cancer staging data and cause of death data are provided to the CSPRG by the NHS Central Register.
No personal data in the UKFSST was transferred out of the CSPRG or Imperial College.
What were the aims of the UKFSST?
The trial aimed to determine whether having a once-only flexible sigmoidoscopy screening test at around age 60 years was effective at preventing bowel cancer and could reduce the number of deaths from this disease. The trial also aimed to determine how long the benefit of the test lasted and the best age for it to be done.
What type of study was the UKFSST?
The UKFSST was a randomised-controlled trial. People who participated in the trial were assigned randomly to receive either flexible sigmoidoscopy screening or the usual care that was offered at the time of the trial, which was no screening. Well-designed randomised controlled studies, such as the UKFSST, are considered to provide the best evidence for whether a new treatment works effectively.
What is the flexible sigmoidoscopy (bowel scope, Flexi-scope) test?
During flexible sigmidoscopy (also called ‘bowel scope’ or Flexi-scope), a narrow, flexible tube with a camera on the end is inserted into the rectum and up into the lower part of the large bowel by a specialist nurse or doctor. Flexible sigmoidoscopy is used to examine the inner surface of the lower bowel for growths, called polyps or adenomas. Polyps are common and are not cancerous, but some can develop into cancer so they are generally removed as part of the procedure, or during a follow up test.
When and where did the study take place?
The UKFSST study recruited people from 506 participating GP practices based in 14 UK centres: 11 in England, two in Wales, and one in Scotland. Recruitment and screening started in November 1994 and were completed in March 1999.
The map below shows the geographical locations of the 14 UK centres that took part in the UKFSST study.
Who is included in the study?
375,744 men and women who were assessed for eligibility for the UKFSST trial included:
- were registered at a participating GP practice between November 1994 and March 1999; and
- were aged 55–64 years between November 1994 and March 1999
Of these, 170,432 people indicated in the study questionnaire or letter sent between September 1994 and March 1999 that they would take up the offer of screening if invited; and were assessed as being eligible for the study; and were randomised. 40,674 of these 170,432 people were screened.
The remaining 205,312 men and women included those who were sent a study questionnaire or letter between September 1994 and March 1999 asking whether they would take up the offer of screening if invited and
- indicated that they would take up the offer of screening if invited and were eligible for the study but were not randomised as 40,000 people had already been screened (funding was given to screen 40,000 people); or
- indicated that they would take up the offer of screening if invited, but were subsequently assessed as not eligible for the study; or
- did not respond to the study questionnaire or letter; or
- responded to the study questionnaire or letter that they would not take up the offer of screening if invited.
What type of information does the CSPRG hold for the purposes of the UKFSST?
The CSPRG holds the following personal information for the purposes of the UKFSST, which covers:
- patient data– name, address, date of birth, NHS number, GP for all individuals in the age range 55-64 years between November 1994 and March 1999 belonging to participating general practices;
- questionnaire data – including responses to various questionnaires sent at different stages of the study, family history of bowel cancer, symptoms, previous examinations and diet and smoking habits;
- clinical information – including medical data collected prior to screening, details of symptoms, results of any medical tests or procedures and blood samples;
- cancer diagnoses (for randomised patients) including histological diagnosis and stage of the disease;
- Records of the deaths of individuals in the age range 55-64 years between November 1994 and March 1999 belonging to participating general practices.
We require the information that we hold in order to answer our research questions and to guarantee the quality and integrity of our results. It will not be possible to identify individuals from the published results of this study.
We have not finished collecting the cancer and death data we need and will continue to do so until March 2027. Our Patient Data section provides further details on what information we hold for the purposes of our research, and how we use and protect this information.
What approvals has this study received?
Everyone who received a flexible sigmoidoscopy as part of the UKFSST gave their consent for this procedure (40,674 people).
Consent was not sought from people who received no further contact other than the initial questionnaire as the group in question was extremely large (335,070 people) and it was not possible to ask for consent from each individual. We received permission to conduct this research study from the independent ethical review committees and organisations responsible for the data of NHS patients, including:
- local research ethics committees in each of the 14 centres and the South-East multicentre research ethics committee;
- Section 251 approval from the Patient Information Advisory Group (PIAG – a predecessor of both the National Information Governance Board/NIGB and the Confidentiality Advisory Group) in England, and an equivalent panel in Scotland, the Privacy Advisory Committee (now the Public Benefit and Privacy Panel for Health and Social Care) of National Services Scotland (NSS);
- Research and Development approval from the NHS Trusts managing the centres involved in the trial;
- approval from the Caldicott Guardian of the North West London NHS Trust;
- approval from the UK Cancer Registries, NHS Digital, NHS Central Register (NHSCR), and the Office for National Statistics (ONS).
Why do we need to hold identifiable data for this study?
We need identifiable data to enable our data providers (such as NHS Digital, NHSCR, NSS, ONS, Cancer Registries and hospitals) to identify the study participants and provide us with follow-up data on cancers/deaths. We hold this data in the public interest (GDPR/DPA 2018: Article 6(1)e) for scientific research (GDPR/DPA 2018: Article 9(2)j)- please see the privacy notice for more information.
How long will we retain the data?
Our original funding allowed us to collect follow-up information on cancers and deaths for the UKFSST until March 2017. We have now been awarded additional funding to continue to follow-up the UKFSST cohort for a further 10 years until March 2027, until all the participants have reached the age of 80 years. Imperial College London, the organisation responsible for this study, requires that we hold data from all clinical studies for 10 years after the study end date. We therefore currently plan to hold the data for this study until March 2037.
What were the results of the study and what impact have they had?
When the first results of the UKFSST were analysed in 2010, they showed that people who were screened just once with flexible sigmoidoscopy (also known as bowel-scope) were:
- less likely to get bowel cancer – it prevented about one in three new cases of bowel cancer;
- less likely to die from the disease – it prevented four in every 10 deaths from bowel cancer.
The protective effects of the once-only flexible sigmoidoscopy also appeared to be long lasting. The UKFSST results were published in The Lancet in 2010.
Because the UKFSST demonstrated that flexible sigmoidoscopy screening can prevent bowel cancer from developing, this suggested that offering a once-only flexible sigmoidoscopy (bowel-scope) screening test to people in the UK should reduce the numbers of people getting bowel cancer and dying from this disease. In 2010, the UK government announced a £60 million investment to introduce bowel scope screening as part of the English NHS Bowel Cancer Screening Programme. Roll-out of bowel-scope screening began in 2013 and is expected to cover the entire population by 2018. It has been estimated that bowel-scope screening could prevent up to 5,000 people from getting bowel cancer and up to 3,000 deaths from the disease in the UK each year. It is hoped that cancer of the rectum, the lowest part of the bowel examined, could one day become a rare disease.
The results of a further 7 years of follow-up were published in The Lancet in Feb 2017 and show that a single flexible sigmoidoscopy continues to provide substantial protection from bowel cancer diagnosis and death, with protection lasting at least 17 years. Cancer Research UK and Imperial College London also published news articles.
In addition to the original study objectives, the UKFSST study team has identified the following potential questions which could be addressed by further analysis of the UKFSST dataset. These analyses will be conducted by the CSPRG medical statisticians and published in peer reviewed journals. No additional data will be requested to meet these objectives.
- Does the quality of flexible sigmoidoscopy screening affect the future risk of getting bowel cancer and dying from this disease?
- Does patient experience and procedural factors affect the performance of flexible sigmoidoscopy screening?
- How safe and acceptable is a once-only flexible sigmoidoscopy?
- How does having a family history of bowel cancer effect the risk of developing this disease after screening?
- Can the severity of disease at diagnosis be used to determine the risk of dying from bowel cancer?
- Among patients identified as higher-risk at their flexible sigmoidoscopy screening, how effective is repeated colonoscopy (examination of the entire bowel) at routine intervals?
- How commonly does bowel cancer in the upper part of the bowel develop after flexible sigmoidoscopy, and can this be predicted by the number and type of polyp detected at flexible sigmoidoscopy?
- Does smoking history affect the risk of developing polyps and bowel cancer?
- Can various medications affect the risk of developing polyps and bowel cancer?
- Among patients taking part in the UKFSST and also invited to take part in the National Bowel Cancer Screening Programme (BCSP), for which they complete Faecal Occult Blood Tests (FOBTs), how do these two screening tests affect the risk of getting bowel cancer?
- Can prior flexible sigmoidoscopy affect participation and outcomes of FOBTs in the BCSP?
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